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Private Research Centre, France, 2005
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Private Research Centre, France, 2005
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The effect of ProgutTM on the
performance of piglets from 21 to 70 days of age. Private research center, France 2005.
Objective
The aim of the stufy was to evaluate the
efficacy of ProgutTM on piglet post weaning performance from 21 days to 70 days of age under typical French
husbandry conditions.
Materials and Methods
The following treatments were tested in the
trial:
| Treatment |
Weaner diet 21-42
days |
Grower diet 42-70
days |
| A Negative Control |
- |
- |
B Positive Control
Avilamycine |
40 ppm |
40 ppm |
| F
ProgutTM |
0.1% |
0.07 % |
| G
ProgutTM |
0.2% |
0.1 % |
| H
ProgutTM |
0.3% |
0.1 % |
At the beginning of the trial 240 (Large
White x Landrace) x P76 piglets were divided into treatments according to sex and initial weight. One treatment was
replicated into 6 pens (8 Piglets per pen); 3 pens of light piglets (around 5 kg) and 3 pens of heavy piglets (around
7kg). The number of male and female piglets per treatment was identical. In order to place animals in a sanitary
situation as close as possible to field sanitary conditions, pens and watering systems were not cleaned nor disinfected
after the previous group. Only faeces and dirt were removed from the floor and drinkers and feeders by
sweeping.
All feeds were offered ad libitum.
Water was supplied continuously via drinkers (1 per pen) from day one until the end of the trial. The trial was divided
into two feeding phases: weaner diets from 21 to 42 days of age and grower diets from 42 to 70 days days. The feed was
provided in pellet form. The compositions of the feeds are presented in the table below. The negative control group
received feed without antibiotics or feed additives (no enzyme, no acidifier and no probiotics). The other feeding
treatments had the same basic formula than the control group, but contained the experimental premix of Avilamycine
(positive control) or ProgutTM at different doses.
|
21-42
days |
42-70
days |
| Wheat |
43 |
38.2 |
| Corn |
- |
5 |
| Barley |
10 |
22 |
| Wheat bran |
- |
5 |
| Extruded wheat |
12 |
- |
| Field peas |
- |
5 |
| Toasted soybean
grain |
12 |
3 |
| Soybean protein concentrate
(HP300) |
2 |
- |
| Palm oil |
- |
1.2 |
| Soybean oil |
0.5 |
- |
| Soybean cake |
11.38 |
15.05 |
| Lactoproduct 40% fat |
2 |
- |
| Lactoserum |
2.8 |
- |
| Dicalcium phosphate |
- |
0.68 |
| Carbonate |
- |
0.4 |
| Monocalcium
phosphate |
1 |
- |
| Salt |
0.31 |
0.42 |
| Synthetic lysine
(78%) |
0.56 |
- |
| Synthetic lysine liquid
(50%) |
- |
0.65 |
| Synthetic methionine |
0.12 |
- |
| Methionine hydroxy
analog |
- |
0.17 |
| Choline chloride (liquid,
75%) |
- |
0.06 |
| Argal |
- |
1.5 |
| Phytase (EC
3.1.3.26) |
- |
0.2 |
| Synthetic threonine
(100%) |
0.23 |
- |
| Threonine (25%) |
- |
0.47 |
| Artificial flavour |
0.10 |
- |
| Vitamin, mineral
premix |
1.50 |
0.5 |
| Experimental premix |
0.50 |
0.5 |
THE COMPOSITION OF THE TRIAL FEED
Piglets were weighed individually at 20, 28,
42 and 70 days of age. All amounts of feeds added to the feeders were weighed as well as remaining feeds in the
feeders. Weight gain, feed intake and feed conversion ratio per treatment was calculated between 21 and 42, 42 and 70,
21 and 70 days of age. Health and mortality was recorded daily.
All zootechnical data was subjected to
analysis of variance, using the UNIANOVA procedure in SPSS 11.0 statistical software. The treatment means were compared
using appropriate means comparison procedures. The statistical model included treatment and weight class as fixed
effects.
Results
Feed compositions were anylised in accordance
with the expected values, except for the threonine content of the grower feed in ProgutTM 0.3/0.1 % group, which was a
bit lower than expected. Mortality in the study was 0.8%
Period 21-42 days
During the first period of the trial
significant differences were observed between the diets for growth performances. The highest growth performances were
observed for the positive control diet and for diet H, which contained 0.3% ProgutTM. Feed conversion ratios didn't
differ significantly between the treatments.
| Treatment |
Weight, kg |
Weight gain g/d |
Feed Intake g/d |
FCR kg/kg |
| A Negative Control |
11.01bc |
239.5bc |
302 |
1.27 |
| B Positive Control |
11.82a |
277.9a |
334 |
1.20 |
| F ProgutTM 0.1/0.07
% |
10.65c |
222.4c |
292 |
1.30 |
| G ProgutTM
0.2/0.1% |
11.19abc |
247.8bc |
310 |
1.26 |
| H ProgutTM 0.3/0.1
% |
11.48ab |
262.7ab |
325 |
1.27 |
PERFORMANCE FROM 21 to 42 DAYS
abc values with different superscripts differ
statistically (P<0.05)
The figure below shows the correlation
between performances and quantity of ProgutTM ingested per day. According to the weight gain equation the
optimal dose of ProgutTM per piget per day was around 1g. This is close to an addition of 0,3%
ProgutTM in the feed during this period (feed intake 300 g/day x 0.3% ProgutTM in the feed = 0.9g
of ProgutTM/piglet/day.

THE CORRELATION BETWEEN PERFORMANCE AND
QUANTITY OF PROGUTTM INJECTED PER DAY
Period 42-70 days
Both the growth and feed conversion ratio in
treatment G (ProgutTM 0.2/0.1) and positive control were significntly better than in the negative control group. Also
piglets in group H (ProgutTM 0.3/0,1%) performed numerically better than the negative control but the differences
weren't statistically significant.
| Treatment |
Weight, kg |
Weight gain g/d |
Feed intake g |
FCR kg/kg |
| A Negative control |
26.11bc |
537.8b |
937 |
1.77b |
| B Positive control |
28.01a |
580.5a |
995 |
1.68ab |
| F ProgutTM
0.1/0.07% |
25.72c |
536.1b |
924 |
1.72ab |
| G ProgutTM
0.2/0.1% |
27.90a |
591.4a |
979 |
1.66a |
| H ProgutTM
0.3/0.1% |
27.24ab |
568.8ab |
990 |
1.74ab |
PERFORMANCE FROM 42-70 DAYS
abc values with different superscripts differ statistically
(P<0.05)
Period 21-70 days
During the whole trial period group G and
positive control had significantly better growth and feed conversion than negative control. Also piglets in the H group
performed numerically better than the negative control but the differences were not statistically
significant.
| Treatment |
weight, kg |
weight gain g/day |
feed intake g |
FCR kg/kg |
| A Negative control |
26.11bc |
410.5bc |
670 |
1.65b |
| B Positive control |
28.01a |
453.9a |
716 |
1.57a |
| F ProgutTM
0.1/0.07% |
25.72c |
400.1c |
658 |
1.63ab |
| ProgutTM
0.2/0.1% |
27.90a |
447.6a |
697 |
1.56a |
| ProgutTM
0.3/0.1% |
27.24ab |
432.5ab |
710 |
1.63ab |
PERFORMANCE FROM 21-70 DAYS
abc values with different superscripts differ statistically
(P<0.05)
The ProgutTM intake per day was
calculated and the correlation between ProgutTM ingestion and performance was studied. The equations below
enabled to calculate and optimum daily dose for growth and feed conversion ratio of 0.9-1g of
Progut/day/piglet.

Conclusions
- During the total trial period from 21 to 70
days of age, ProgutTM, at two higher doses improved the piglet performance in comparison with the negative control
group.
- The improvement in performance was
positively linked to the dose of ProgutTM ingested per day
- The optimum dose of ProgutTM for the whole
trial period was identified to be 0.9-1g of Progut/piglet/day
- The optimum dose corresponds to 0.3% of
ProgutTM from 21 to 42 days and 0.1% of ProgutTM from 42 to 70 days.
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